La fibromialgia (FM) se caracteriza por dolor crónico generalizado, sueño no reparador, agotamiento físico y dificultades cognitivas. Only a minority of patients experience substantial symptom relief with duloxetine, milnacipran, and pregabalin. Evidence-based interdisciplinary guidelines give a strong recommendation for aerobic exercise and cognitive behavioral therapies. The diagnosis can be established in most cases by a general practitioner when the symptoms meet recognized criteria and a somatic disease sufficiently explaining the symptoms is excluded. The various classification systems according to pain medicine, psychiatry, and neurology (pain disease persistent somatoform pain disorder masked depression somatic symptom disorder small fiber neuropathy brain disease) mostly capture only some components of this complex and heterogeneous disorder. Definition, pathogenesis, diagnosis, and treatment of FM remain points of contention, with some even contesting its existence. It occurs in all populations throughout the world, with prevalence between 2% and 4% in general populations. Fibromyalgia (FM) is characterized by chronic widespread pain, unrefreshing sleep, physical exhaustion, and cognitive difficulties.
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